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Member Feature: University of Minnesota

June 1, 2019:

Investigator Spotlight:

Robert Kratzke, MD, University of Minnesota

Research interests:

I am a medical oncologist with a particular interest in lung cancer and mesothelioma. In my laboratory we are currently looking at the use of viruses for cancer therapy. In particular, the vesicular stomatitis virus (VSV) interests us as it preferentially infects cancer cells without causing disease in humans. We have shown that injecting the virus at one tumor will rapidly lead to infection in other tumor sites throughout the body. Also, the infection of the cancer cells not only kills malignant cells, it elicits an immune response that helps attack surrounding cancer cells without harming normal cells. Finally, this enhanced immune response makes the infected cancer cells more vulnerable to treatment with the modern immunotherapies such as pembroluzimab or nivolumab. In collaboration with Dr. Manish Patel we are currently running clinical studies at the UMMC using VSV. Read More

The Cancer Center at Illinois joins the Big Ten CRC

May 30, 2019: The Cancer Center at Illinois (CCIL) has joined the Big Ten Cancer Research Consortium (Big Ten CRC). Located at the University of Illinois at Urbana-Champaign, the CCIL develops new insights, tools, and technologies to fight cancer and moves those advances into clinical practice. The CCIL unites historic campus strengths in basic science and engineering to develop new ways to prevent, diagnose, and treat cancer, enabling people to live cancer-free lives. Read More

Two Big Ten CRC studies selected as ASCO 2019 posters

May 30, 2019: Two Big Ten Cancer Research Consortium studies, BTCRC-LUN16-081 and BTCRC-ESO14-012, will be presented during the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, May 31 - June 4, in Chicago. BTCRC-LUN16-081, a phase II study of consolidation immunotherapy with nivolumab and ipilimumab or nivolumab alone following concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer (NSCLC), will be featured during a poster session on Sunday, June 2. The study is led by Greg Durm, MD, of the Indiana University Melvin and Bren Simon Cancer Center. Read More

The Ohio State University’s cancer center joins the Big Ten CRC

May 29, 2019: The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) has joined the Big Ten Cancer Research Consortium (Big Ten CRC). Through membership in the consortium, cancer researchers from The Ohio State University may participate in the Big Ten CRC’s Clinical Trial Working Groups, submit letters of intent (LOIs) to the working groups for consideration as Big Ten studies, and collaborate with researchers from other Big Ten cancer centers on clinical trials. Based in Columbus, Ohio, the OSUCCC – James is the... Read More

Across the Consortium: May 2019

May 28, 2019: In this month’s Across the Consortium, the Big Ten Cancer Research Consortium (Big Ten CRC) highlights new treatments, early cancer detection methods, and research that is revealing more about the science of cancer and how it spreads. We also welcome two new members to the Big Ten CRC: The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, and the Cancer Center at Illinois (University of Illinois at Urbana-Champaign). We look forward to their contributions to the Big Ten CRC! Read More

Big Ten CRC phase II study for peripheral T cell lymphoma patients tests combined treatment of nivolumab and cabiralizumab

May 7, 2019: The University of Michigan is leading a Big Ten Cancer Research Consortium study that will test the immunotherapy drug nivolumab combined with the anti-CSF-1R monoclonal antibody cabiralizumab in patients with relapsed or refractory peripheral T cell lymphoma (PTCL). The study is now open for accrual at the University of Michigan Rogel Cancer Center. The study, BTCRC-HEM16-085, “Phase II study of nivolumab and the antagonistic CSF-1R monoclonal antibody cabiralizumab (BMS-986227) in patients with relapsed/refractory peripheral T cell lymphoma,” will help researchers determine the number of patients whose tumors shrank after receiving this therapy, and how long this response lasts before the tumors start to grow again.... Read More

Big Ten CRC announces ASCO 2019 meetings

May 3, 2019: The Big Ten Cancer Research Consortium will host meetings for the Big Ten CRC Foundation, Cancer Center Directors, Steering Committee, and Clinical Trial Working Groups during ASCO 2019. Read More

Member Feature: University of Illinois Cancer Center

May 1, 2019: Investigator Spotlight: Ardaman Shergill, MD, University of Illinois Research interests: Dr. Shergill has a broad clinical practice where she treats patients with a variety of cancers. Her mission: Bring high quality, evidence-based, state-of-the-art care to all her patients, and deliver it in the most compassionate way possible. Her interest in cancer is due to having lost loved ones to the disease, giving her a unique and humbling insight into a patient’s experience with the illness. Dr. Shergill is interested in helping develop and improve access to novel promising therapeutic advances for her patients so they may benefit from the latest research that is occurring in the rapidly changing field of oncology. She has extensive experience in clinical trials and... Read More

Big Ten CRC study tests combination of ixazomib and romidepsin in relapsed or refractory peripheral T-cell lymphoma

April 29, 2019: A Big Ten Cancer Research Consortium phase I/II study is testing the safety and efficacy of combining ixazomib and romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). The study is now open for accrual at the University of Michigan Rogel Cancer Center, Rutgers Cancer Institute of New Jersey, the University of Illinois Cancer Center in Chicago, and Holden Comprehensive Cancer Center at the University of Iowa. Read More

Across the Consortium: April 2019

  April 16, 2019: In this month’s Across the Consortium, the Big Ten CRC highlights a variety of initiatives, including treatment for children with leukemia, research for future vaccines against cancer, and research to prolong the lives of those fighting some of the most deadly cancers; and we honor cancer advocates who have lost their own battles with cancer. Read More

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