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Member Feature: Purdue University Center for Cancer Research

June 6, 2018:

Investigator Spotlight

Emily Dykhuizen, PhD Purdue University Center for Cancer Research 

Educational Background

  • BA, Reed College, Biochemistry and Molecular Biology
  • PhD, UW-Madison, Chemistry
  • Postdoc, Stanford University, Chromatin Biology

Research Interests

My lab works on understanding the role of chromatin regulation on cancer initiation and progression. More specifically, we look at how chromatin regulators regulate gene expression in response to environmental changes. From this information we outline how patient mutations found in chromatin regulators cooperate with the metabolic environment to promote cancer. We then develop strategies to inhibit these pathways to treat a variety of highly chemoresistant cancers such as glioblastoma, kidney cancer, and ovarian cancers.

My lab collaborates with chemists, structural biologists, biochemists and cancer biologists across the Big Ten to identify how chromatin regulators contribute to cancer initiation, cancer metastasis and chemotherapy resistance, and most importantly, to identify how we can target these processes with novel small molecules to help patients with deadly cancers.

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Two Big Ten CRC studies accepted to ASCO 2018

June 2, 2018: Two Big Ten Cancer Research Consortium studies were accepted as abstracts to the American Society of Clinical Oncology (ASCO) Annual Meeting, June 1-5, 2018, at the McCormick Place in Chicago. The BTCRC-GU14-003 study was presented during a poster session on Saturday, June 2, while the BTCRC-ESO14-012 study was accepted for publication. Arkadiusz Dudek, MD, PhD (left), is sponsor-investigator of BTCRC-GU14-003, and Shadia Jalal, MD, is sponsor-investigator of BTCRC-ESO14-012. BTCRC-GU14-003 was the Big Ten CRC's first study to open to accrual, and completed enrollment about six months ahead of schedule. Read More

Across the Consortium: May 2018

May 21, 2018: On your MARK, get SET, GO Across the Consortium! Get up to date on recent clinical trial outcomes; big leaps in funding; and diagnostic breakthroughs with far-reaching implications. Be inspired by the Big Ten CRC Member Institutions as you witness researchers tackling the toughest questions in oncology as a team. Read More

Member Feature: Penn State Cancer Institute

May 12, 2018: Investigator Spotlight Monika Joshi, MD, MRCP, Penn State Cancer Institute  Educational Background MB, BS, Kasturba Medical College, Manipal Academy of Higher Education Member of Royal College of Physicians, London MD Residency, Internal Medicine, Pinnacle Health Hospitals Hematology/Oncology Fellowship, Penn State Cancer Institute, Penn State Health Milton S. Hershey Medical Center Research Interests My clinical and research interests lie primarily in the field of genitourinary (GU) tumors, developing novel therapeutic combinations and biomarkers for GU cancer of the bladder, kidney and prostate. I have a keen interest in developing novel combination... Read More

Researchers test FOLFOX plus nab-paclitaxel in metastatic or advanced unresectable gastric/gastroesophageal junction cancer

May 2, 2018: A Big Ten Cancer Research Consortium study, led by investigators at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, could help determine whether an investigational combination of chemotherapy drugs might lead to improved overall responses in patients with metastatic or advanced unresectable gastric/gastroesophageal junction cancer. The goal of the single-arm, phase II study, known as BTCRC-GI15-015, is to estimate the overall objective response rate in subjects receiving the combination of FOLFOX and nab-paclitaxel (FOLFOX-A). Read More

Big Ten CRC announces ASCO 2018 meetings

May 1, 2018: The Big Ten Cancer Research Consortium will host meetings for the Big Ten CRC Foundation, Cancer Center Directors, Steering Committee, and Clinical Trial Working Groups during ASCO 2018. Read More

Across the Consortium: April 2018

April 16, 2018: Every month, we huddle for another edition of Across the Consortium to recap the progress of our member institutions. Here are this month's hand-picked highlights from across the consortium! Be inspired as you catch all the action.  Read More

April is National Cancer Control Month

April 14, 2018: As stated in the American Cancer Society’s Cancer Facts & Figures, in 2018, there will be an estimated 1,735,350 new cancer cases diagnosed and 609,640 cancer deaths in the United States. While cancer treatments and early detection have become more and more promising over the years – thus increasing life expectancy and lowering the mortality rate of cancer patients – prevention remains one of the most important challenges. Read More

Across the Consortium – March 2018

March 25, 2018: Across the Consortium is your instant replay of Big Ten CRC member news. This month we highlight colon cancer screen options and advice; advancements in technology to provide better understanding of cancer spread; new strategy for treating pancreatic cancer; cutting edge cell therapies; and more! Read More

Science without boundaries: Purdue researchers strengthen correlative expertise within Big Ten CRC

March 5, 2018: What do plant molecular biologists, chemical engineers, veterinarians, biomedical engineers, and analytical chemists from around the world have in common? Everything - at Purdue University - including correlative cancer research. "We work with people across campus and across the state that need our particular technical expertise," says Jill Hutchcroft, PhD, director of Purdue's Flow Cytometry and Cell Separation Facility. Purdue researchers in Dr. Jill Hutchcroft's lab"Our samples come from engineers, biologists, and chemists; our technology bridges many disciplines as people are trying to cross boundaries," says Hutchcroft. "We are really a connection between many different disciplines. We work with everything from human tumors to zebra fish to corn, and we work with many model systems. Our work... Read More

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